解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Despite significant advances in the fabrication and applications of graphene-like materials, it remains a challenge to prepare single-layered metallic materials, which have great potential applications in physics, chemistry and material science. Here we report the fabrication of poly(vinylpyrrolidone)-supported single...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4093
更新日期:2014-01-01 00:00:00
abstract::The polypterids (bichirs and ropefish) are extant basal actinopterygian (ray-finned) fishes that breathe air and share similarities with extant lobe-finned sarcopterygians (lungfishes and tetrapods) in lung structure. They are also similar to some fossil sarcopterygians, including stem tetrapods, in having large paire...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4022
更新日期:2014-01-01 00:00:00
abstract::Membranes with nano-apertures are versatile templates that possess a wide range of electronic, optical and biomedical applications. However, such membranes have been limited to silicon-based inorganic materials to utilize standard semiconductor processes. Here we report a new type of flexible and free-standing polymer...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4137
更新日期:2014-01-01 00:00:00
abstract::The force generated by the actomyosin cytoskeleton controls focal adhesion dynamics during cell migration. This process is thought to involve the mechanical unfolding of talin to expose cryptic vinculin-binding sites. However, the ability of the actomyosin cytoskeleton to directly control the formation of a talin-vinc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4095
更新日期:2014-01-01 00:00:00
abstract::The control of the magnetization of a material with an electric field would make the design and the integration of novel electronic devices possible. This explains the renewed interest in multiferroic materials. Progress in this field is currently hampered by the scarcity of the materials available and the smallness o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4167
更新日期:2014-01-01 00:00:00
abstract::Theory predicts a trade-off between investments in precopulatory (ornaments and armaments) and postcopulatory (testes and ejaculates) sexual traits due to the costs associated with their growth and maintenance within the finite energy resources available. Empirical studies, however, have revealed considerable inconsis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4184
更新日期:2014-01-01 00:00:00
abstract::Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the effects of averaging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4220
更新日期:2014-01-01 00:00:00
abstract::Animal propulsors such as wings and fins bend during motion and these bending patterns are believed to contribute to the high efficiency of animal movements compared with those of man-made designs. However, efforts to implement flexible designs have been met with contradictory performance results. Consequently, there ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4293
更新日期:2014-01-01 00:00:00
abstract::The reconstruction of human-driven, Earth-shaping dynamics is important for understanding past human/environment interactions and for helping human societies that currently face global changes. However, it is often challenging to distinguish the effects of the climate from human activities on environmental changes. He...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/ncomms4211
更新日期:2014-01-01 00:00:00
abstract::Loss of seed dispersal is a key agronomical trait targeted by ancient human selection and has been regarded as a milestone of crop domestication. In this study, in the legume crop soybean Glycine max (L.) Merr. which provides vegetable oils and proteins for humans, we show that the key cellular feature of the shatteri...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4352
更新日期:2014-01-01 00:00:00
abstract::Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4063
更新日期:2014-01-01 00:00:00
abstract::Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4309
更新日期:2014-01-01 00:00:00
abstract::The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Here we report that Yes-associated protein (YAP), the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4315
更新日期:2014-01-01 00:00:00
abstract::Two-component signal transduction systems consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to environmental cues. Most activated response regulators regulate transcription by binding tightly to promoter DNA via a phosphorylation-triggered inactive-to-active transition. Th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4282
更新日期:2014-01-01 00:00:00
abstract::Room-temperature infrared sub-band gap photoresponse in silicon is of interest for telecommunications, imaging and solid-state energy conversion. Attempts to induce infrared response in silicon largely centred on combining the modification of its electronic structure via controlled defect formation (for example, vacan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4011
更新日期:2014-01-01 00:00:00
abstract::Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4127
更新日期:2014-01-01 00:00:00
abstract::Graphene and hexagonal boron nitride are typical conductor and insulator, respectively, while their hybrids hexagonal boron carbonitride are promising as a semiconductor. Here we demonstrate a direct chemical conversion reaction, which systematically converts the hexagonal carbon lattice of graphene to boron nitride, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4193
更新日期:2014-01-01 00:00:00
abstract::The Aharonov-Bohm effect is one of the most intriguing phenomena in both classical and quantum physics, and associates with a number of important and fundamental issues in quantum mechanics. The Aharonov-Bohm effects of charged particles have been experimentally demonstrated and found applications in various fields. R...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4225
更新日期:2014-01-01 00:00:00
abstract::IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+ CD4+ T cells is Treg-/Foxp3-indepen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4199
更新日期:2014-01-01 00:00:00
abstract::Dislocation defects together with their associated strain fields and segregated impurities are of considerable significance in many areas of materials science. However, their atomic-scale structures have remained extremely challenging to resolve, limiting our understanding of these ubiquitous defects. Here, by develop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4239
更新日期:2014-01-01 00:00:00
abstract::Conventional interferometers usually utilize beam splitters for wave splitting and recombination. These interferometers are widely used for precision measurement. Their sensitivity for phase measurement is limited by the shot noise, which can be suppressed with squeezed states of light. Here we study a new type of int...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4049
更新日期:2014-01-01 00:00:00
abstract::Polymers bearing dynamic covalent bonds may exhibit dynamic properties, such as self-healing, shape memory and environmental adaptation. However, most dynamic covalent chemistries developed so far require either catalyst or change of environmental conditions to facilitate bond reversion and dynamic property change in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4218
更新日期:2014-01-01 00:00:00
abstract::The TORC1 complex controls cell growth upon integrating nutritional signals including amino-acid availability. TORC1 notably adapts the plasma membrane protein content by regulating arrestin-mediated endocytosis of amino-acid transporters. Here we demonstrate that TORC1 further fine tunes the inherent activity of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4101
更新日期:2014-01-01 00:00:00
abstract::Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4224
更新日期:2014-01-01 00:00:00
abstract::Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3957
更新日期:2014-01-01 00:00:00
abstract::Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4346
更新日期:2014-01-01 00:00:00
abstract::The welding and sintering of nanomaterials is relevant, for example, to form electrical contacts between metallic particles in printed electronic devices. Usually the welding of nanoparticles is achieved at high temperatures. Here we find that merging of two different metals, silver and gold nanoparticles, occurs on c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3994
更新日期:2014-01-01 00:00:00
abstract::High-performance piezoelectrics are lead-based solid solutions that exhibit a so-called morphotropic phase boundary, which separates two competing phases as a function of chemical composition; as a consequence, an intermediate low-symmetry phase with a strong piezoelectric effect arises. In search for environmentally ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4172
更新日期:2014-01-01 00:00:00
abstract::The high Aβ42/Aβ40 production ratio is a hallmark of familial Alzheimer's disease, which can be caused by mutations in the amyloid precursor protein (APP). The C-terminus of Aβ is generated by γ-secretase cleavage within the transmembrane domain of APP (APPTM), a process that is primed by an initial ε-cleavage at eith...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4037
更新日期:2014-01-01 00:00:00
abstract::Quantum fluctuations give rise to van der Waals and Casimir forces that dominate the interaction between electrically neutral objects at sub-micron separations. Under the trend of miniaturization, such quantum electrodynamical effects are expected to play an important role in micro- and nano-mechanical devices. Nevert...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2842
更新日期:2013-01-01 00:00:00
abstract::To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3325
更新日期:2013-01-01 00:00:00
abstract::The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3258
更新日期:2013-01-01 00:00:00
abstract::Stackable select devices such as the oxide p-n junction diode and the Schottky diode (one-way switch) have been proposed for non-volatile unipolar resistive switching devices; however, bidirectional select devices (or two-way switch) need to be developed for bipolar resistive switching devices. Here we report on a ful...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3629
更新日期:2013-01-01 00:00:00
abstract::Gold recovery using environmentally benign chemistry is imperative from an environmental perspective. Here we report the spontaneous assembly of a one-dimensional supramolecular complex with an extended {[K(OH₂)₆][AuBr₄](α-cyclodextrin)₂}n chain superstructure formed during the rapid co-precipitation of α-cyclodextrin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2891
更新日期:2013-01-01 00:00:00
abstract::Selective thermal emission in a useful range of energies from a material operating at high temperatures is required for effective solar thermophotovoltaic energy conversion. Three-dimensional metallic photonic crystals can exhibit spectral emissivity that is modified compared with the emissivity of unstructured metals...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3630
更新日期:2013-01-01 00:00:00
abstract::Bright solitons are non-dispersive wave solutions, arising in a diverse range of nonlinear, one-dimensional systems, including atomic Bose-Einstein condensates with attractive interactions. In reality, cold-atom experiments can only approach the idealized one-dimensional limit necessary for the realization of true sol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2893
更新日期:2013-01-01 00:00:00
abstract::Efficient and low-cost electrocatalysts for the oxygen evolution reaction are essential components of renewable energy technologies, such as solar fuel synthesis and providing a hydrogen source for powering fuel cells. Here we report that the nitrogen-doped carbon materials function as the efficient oxygen evolution e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3390
更新日期:2013-01-01 00:00:00
abstract::Protein function and dynamics are closely related; however, accurate dynamics information is difficult to obtain. Here based on a carefully assembled data set derived from experimental data for proteins in solution, we quantify backbone dynamics properties on the amino-acid level and develop DynaMine--a fast, high-qua...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3741
更新日期:2013-01-01 00:00:00
abstract::Biological clocks have evolved as an adaptation to life on a rhythmic planet, synchronising physiological processes to the environmental light-dark cycle. Here we examine circadian clock function in Mexican blind cavefish Astyanax mexicanus and its surface counterpart. In the lab, adult surface fish show robust circad...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3769
更新日期:2013-01-01 00:00:00
abstract::Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome Beadchip, in search ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3872
更新日期:2013-01-01 00:00:00